Gabapentin and Pressor Response to Intubation (NCT06705101) | Clinical Trial Compass
Not Yet RecruitingPhase 1/2
Gabapentin and Pressor Response to Intubation
144 participantsStarted 2024-12-15
Plain-language summary
This study evaluates the effectiveness of oral gabapentin in reducing the pressor response (increased MAP, HR, and BP) during laryngoscopic intubation. It is a prospective, double-blind randomized controlled trial involving 144 patients undergoing elective surgery. Gabapentin 300 mg or placebo will be administered preoperatively, with hemodynamic parameters monitored before and after intubation. The study aims to determine if gabapentin attenuates the sympathetic stress response compared to placebo.
Who can participate
Age range
18 Years – 59 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* ASA I or II patients (American Society of Anesthesiologists Physical Status Classification).
* Age between 18 and 59 years.
* Scheduled for elective surgery under general anesthesia with endotracheal intubation.
Exclusion Criteria:
* Anticipated difficult intubation.
* ASA III or greater.
* Patients with hiatus hernia or gastro-esophageal reflux disease (GERD).
* Body weight more than 20% of ideal body weight.
* Patients on antihypertensive drugs, sedatives, hypnotics, or antidepressants.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Mean Arterial Pressure (MAP)
Timeframe: 2 minutes, and 5 minutes after laryngoscopy and tracheal intubation
Trial details
NCT IDNCT06705101
SponsorLiaquat National Hospital & Medical College