Glucosyltransferases (Gtfs) play a crucial role in the pathogenesis of dental caries caused by Streptococcus mutans. Gtfs is recognized as an attractive target for effective therapeutic interventions aimed at inhibiting cariogenic biofilms. Objective: This study evaluates the antibacterial effects of sage extract compared to chlorhexidine mouthwashes on the expression of Gtf genes in S. mutans from salivary samples of high caries risk patients over a one-month follow-up, utilizing real-time polymerase chain reaction. Methodology: This clinical trial involves 42 participants with a high risk for caries, who are randomly divided into two groups of 21 subjects each.
Age range
20 Years – 50 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
real-time PCR
Timeframe: 1 week
real-time PCR
Timeframe: 2 weeks
real-time PCR
Timeframe: 3 weeks
real-time PCR
Timeframe: 4 weeks
Gene Expression
Timeframe: 1 week
Gene Expression
Timeframe: 2 weeks
Gene Expression
Timeframe: 3 weeks
Gene Expression
Timeframe: 4 weeks