RecruitingNot Applicable

Neural Correlates of Movement Disorders Associated With PRRT2 Related Paroxysmal Kinesigenic Dyskinesia - an Ancillary Study of AMEDYST Research

France1 participantsStarted 2025-01-21

Plain-language summary

The main objective of this study is to investigate in real-time the neuronal correlates of paroxysmal dyskinesia episodes related to the PRRT2 mutation within this subgroup of patients (who can control paroxysmal dyskinesia episodes), and more specifically, the pathological role of the reciprocal influence between the striatum and the cerebellum in paroxysmal dyskinesia episodes.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion Criteria: Male or female Individuals with dystonic disease carrying a PRRT2 mutation and demonstrating the ability to control paroxysmal dyskinesia episodes. Affiliated with a health insurance system or a beneficiary of such a system. Individuals aged 18 to 75 years. Signature of informed consent Exclusion Criteria: Individuals under guardianship. Individuals not residing in France. Individuals unable to comply with protocol constraints (compliance with visit schedules and ability to perform required tasks). Individuals undergoing an exclusion period for another research study. Contraindications to MRI

What they're measuring

BOLD signal amplitude

Timeframe: Visit 1 to 5

EEG signal amplitude

Timeframe: Visit 6 to 10

Trial details

NCT IDNCT06701851

SponsorInstitut National de la Santé Et de la Recherche Médicale, France

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2028-01

Contact for this trial

Emmanuel Roze, MD, PhD

+33142162748 emmanuel.flamand-roze@psl.aphp.fr

View on ClinicalTrials.gov More Paroxysmal Dyskinesia trials