CompletedNot Applicable

Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer

Finland107 participantsStarted 2022-03-28

Plain-language summary

The goal of this observational study is to evaluate whether the active-matrix metalloproteinase-8 (aMMP-8) mouth-rinse test can help detect oral and oropharyngeal cancers. Researchers measured aMMP-8 levels in mouth-rinse samples collected from 77 cancer participants and 50 non-cancer participants in a clinical setting. The main question this study seeks to answer: Can the aMMP-8 mouth-rinse test accurately identify and differentiate cancer participants from non-cancer participants in real-time?

Who can participate

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Biopsy-confirmed oral or oropharyngeal cancer identified by the following International Classification of Diseases (ICD-10) codes: C00-C06, C08-C10, C13, and C32 according to the American Joint Committee on Cancer (AJCC) 8th Edition * Adult Exclusion Criteria: * In-situ cancer * Previous cancer diagnosis within five years prior to the examination * Use of tetracyclines at the time of sampling * Did not follow the manufacturer's instructions prior to the mouth-rinse sample (i.e. brushing teeth before sampling)

What they're measuring

aMMP-8 levels and status in mouth rinse-samples measured utilizing aMMP-8 Point-of-Care Test

Timeframe: Within two hours from initial sample obtained for this study

Trial details

NCT IDNCT06701058

SponsorHelsinki University Central Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-09-01

View on ClinicalTrials.gov More Oropharyngeal Cancers trials