By InvitationNot Applicable

Characterizing the EEG Signature of Fentanyl and Its Association With Drug Liking

United States20 participantsStarted 2025-02-04

Plain-language summary

The goal of this study is to characterize an electroencephalogram (EEG) biomarker for fentanyl and understand where this signal is coming from in the brain. The investigators also aim to understand how this EEG biomarker is connected to patient perception to drug liking.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. 18 years old or above (male and female)
✓. American Society of Anesthesiologists (ASA) physical status classification of I, II or III
✓. Candidates scheduled for general surgical procedures under general anesthesia and receive fentanyl for surgery

Exclusion criteria

✕. Craniofacial abnormalities
✕. Known or suspected difficult intubation or mask ventilation
✕. Known or suspected need for rapid sequence induction and intubation
✕. Body mass index above 45 kg/m2
✕. Allergies to fentanyl
✕. History of obstructive sleep apnea requiring CPAP
✕. History of obstructive or restrictive lung disease
✕. Opiate use within 24 hours

What they're measuring

Source Localization of Fentanyl EEG Signature

Timeframe: 15 minutes prior to surgery

Trial details

NCT IDNCT06699953

SponsorStanford University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-31

View on ClinicalTrials.gov More Brain Activity Related to Opioid Administration trials