Risk Factors and Disorders Linked to Uterine Adenomyosis on MRI in Reproductive-Age Women (NCT06697444) | Clinical Trial Compass
CompletedNot Applicable
Risk Factors and Disorders Linked to Uterine Adenomyosis on MRI in Reproductive-Age Women
Iran50 participantsStarted 2021-01-01
Plain-language summary
The goal of this observational case-control study is to identify risk factors and associated conditions related to adenomyosis in women of reproductive age.
The main questions it aims to answer are:
Is there an association between a history of uterine surgery and the occurrence of adenomyosis? Does a higher prevalence of endometriosis or increased number of pregnancies correlate with adenomyosis? Researchers will compare women with MRI-confirmed adenomyosis to a control group of women who underwent pelvic MRI for other reasons but were not diagnosed with adenomyosis to see if there are significant differences in risk factors such as endometriosis, number of pregnancies, and history of uterine surgery.
Participants will:
Undergo pelvic MRI with and without intravenous contrast Provide information on factors such as age, smoking, number of pregnancies, history of uterine surgery, and coexisting conditions like leiomyoma and ovarian cysts This study aims to inform better management strategies for reducing the incidence of adenomyosis by targeting modifiable risk factors.
Who can participate
Age range
50 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Women of reproductive age (18-50 years).
* Patients who underwent pelvic MRI for clinical indications.
* MRI-confirmed diagnosis of adenomyosis (for the case group).
* Patients without adenomyosis confirmed by MRI (for the control group).
* Willingness to participate and provide informed consent.
Exclusion Criteria:
* Women outside the reproductive age range (under 18 or over 50 years).
* Pregnancy or lactation at the time of MRI.
* Previous hysterectomy or other major uterine surgeries.
* Presence of malignancies or other serious conditions that could interfere with the study.
* Inability to undergo MRI due to contraindications (e.g., metal implants, pacemakers).
* Incomplete or missing MRI data.
* Non-consent to participate in the study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Prevalence of Endometriosis in Participants Diagnosed with MRI-Confirmed Adenomyosis
Timeframe: From admission to discharge, up to 1 week