Effort and Antidepressant Study Test (NCT06696482) | Clinical Trial Compass
Not Yet RecruitingPhase 1/2
Effort and Antidepressant Study Test
50 participantsStarted 2025-01
Plain-language summary
The aim of this study is to investigate the behavioural effects and neural correlates of increasing serotonin levels in healthy volunteers, through a 7-day course of the SSRI escitalopram, on an effort-based decision-making task measuring self-benefiting and prosocial behaviours.
Who can participate
Age range18 Years – 40 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participant is willing and able to give informed consent for participation in the research
* Aged 18 to 40 years
* Sufficient knowledge of English language to understand and complete study tasks
* Right-handed
Exclusion Criteria:
* Current or past probable diagnosis of psychiatric illness, according to DSM-5 criteria requiring intervention by a healthcare professional, including but not limited to psychosis, bipolar disorder, major depression, OCD, PTSD, substance abuse disorder or any eating disorder
* Current or past diagnosis of any significant personality disorder (e.g., borderline personality disorder) according to self-report
* Diagnosis of attention deficit hyperactive disorder or autistic spectrum disorder that impairs daily functioning, requires pharmacotherapy or in the opinion of the study medic would affect the scientific integrity of the study
* Current use of medication that might interact with the effects of escitalopram or affect the scientific integrity of the study
* Previous suicide attempt or previous prolonged period (eg., \> 5 days) of thought to end life
* Known contraindication to escitalopram including: past allergic reaction to escitalopram or any other medicines, diagnosis of angle-closure glaucoma, or current use of any other medication whose use interacts with escitalopram (according to BNF guidance) e.g. associated with prolonged QT-interval
* Any other current or past medical conditions which in the opinion of the study …
What they're measuring
1
Effort-based decision-making task for self-benefiting and prosocial behaviours: behavioural correlates
Timeframe: Day 7 of treatment
2
Effort-based decision-making for self-benefiting and prosocial behaviours: Neural correlates