The Role of Precision Anesthesia Strategy on Perioperative Organ Protection in Hip Surgery [PASPOP] (NCT06696404) | Clinical Trial Compass
CompletedNot Applicable
The Role of Precision Anesthesia Strategy on Perioperative Organ Protection in Hip Surgery [PASPOP]
China90 participantsStarted 2024-12-01
Plain-language summary
The goal of this clinical trial is to investigate the effect of three anesthetic strategies on organ protection in elderly patients undergoing hip fracture surgery.
The main questions it aims to answer are: 1.Does the nerve block anesthesia group have a protective effect on the incidence of postoperative delirium in elderly patients undergoing hip surgery? 2.Does the nerve block anesthesia group also provide protective effects on other organs for elderly patients undergoing hip surgery? 3.What effects will these anesthetic strategies have on short-term and long-term prognosis of elderly patients undergoing hip surgery?
The investigators will compare it with the spinal anesthesia group and the general anesthesia group to see which has a better protective effect on organs.
Participants will undergo preoperative interviews and will be interviewed twice daily, in the morning and evening, from postoperative day 1 to 7 or until discharge, to assess the occurrence of delirium and cognitive levels, pain intensity, and sleep status.
Interventions:
1. Nerve block anesthesia group (NA group): Combined Lumbar and Sacral Plexus Block + sedation or laryngeal mask anesthesia
2. General anesthesia group (GA group): General anesthesia (Endotracheal intubation) + iliac fascial block
3. Spinal anesthesia group (SA group): Spinal anesthesia without any nerve blockade
Who can participate
Age range
65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Aged 65 years and older
. American Society of Anesthesiologists (ASA) physical status 1 to 3
. Scheduled for unilateral hip surgery
Exclusion criteria
. Have psychiatric disorders or cognitive impairments, or are unable to understand the scale
. Have a heart failure history (EF \< 40) or a history of AMI in 3 months
. Complex injuries: multiple fractures, chest, abdomen, pelvic and sacral trauma, head trauma, etc.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Incidence of of postoperative delirium
Timeframe: From enrollment to the seventh day after surgery or before discharge
Trial details
NCT IDNCT06696404
SponsorShanghai Jiao Tong University Affiliated Sixth People's Hospital
. Combined with respiratory failure or hepatic failure (Child-Pugh C) or renal failure (rely on dialysis treatment)
. Nerve block contraindication: puncture site infection, peripheral neuropathy, regional anesthetic allergy, etc.
. Contraindications of intraspinal anesthesia: coagulation dysfunction, thrombocytopenia, intraspinal space occupying, infection of puncture site, etc.
. Relative contraindications of general anesthesia: known difficult airway, malignant hyperthermia, etc.