Effectiveness of an Air Purifier on Asthmatic and Cat-allergic Subjects in the ALYATEC Environmental Exposure Chamber

Inclusion Criteria: * Subjects who signed the written informed consent * Men or women aged between 18- and 65-year-old * Subjects covered by health social identification number * Subjects able to understand and complete study-related procedures * Subjects reported history of symptomatic cat allergen-triggered asthma (GINA1-2) with or without associated allergic rhinitis and/or conjunctivitis * Positive skin prick test (SPT) with cat hair extract with mean wheal diameter ≥ 5 mm compared to negative control (NaCl reaction \< 2 mm) * Subjects with FEV1≥70% predicted at screening and before allergen exposure, * Subjects with at least one drop in FEV1 ≥ 20% within the 2- hours exposure at baseline (V2) * Women of childbearing potential with a negative pregnancy test throughout the study period and highly effective contraception: oral contraceptives, condom with spermicide, intrauterine device, bilateral tubal ligation, vasectomized partner. Exclusion Criteria: * Allergen immunotherapy to cat allergen for more than 1 month in the 3 years prior to the screening visit * Ongoing allergen immunotherapy to another allergen * History of anaphylactic reactions to cat allergen exposure or cat allergen immunotherapy * History of anaphylactic reactions to another allergen in the last 6 weeks before inclusion * Nasal polyposis, deviation of nasal septum, or diagnosis of uncontrolled non- allergic rhinitis * Subjects allergic to indoor environmental allergens (molds, house dust mite allerge…