Efficacy and Safety of Platelet-rich Plasma, Metformin and Cryotherapy in Treatment of Non-genital Warts

Inclusion Criteria: * Patients with cutaneous (extragenital) viral warts (single , new or recurrent, common, plane and/or planter warts. * Age ranged from 8 to 60 years old. * No concurrent systemic or topical treatment of warts. Exclusion Criteria: * Patients with fever or signs of any inflammation or infection * Pregnancy and lactation. * Immunosuppression or being under any kind of treatment causing absolute or relative immunosuppression. * History of any bleeding, clotting disorder or using anticoagulants * Chronic systemic diseases such as diabetes, chronic renal failure, hepatic insufficiency, and cardiovascular disorders. * atients using concurrent treatments for warts or one month before . * Any generalized dermatitis, allergic skin disorders