Of patients requiring mechanical ventilation in the ICU 23% meet criteria of the Acute Respiratory Distress Syndrome (ARDS). Mortality of this syndrome remains high (35-46%) in moderate and severe ARDS. In patients not recovering from ARDS, fibroblasts seem to play an important role. However, the effect of fibroblast activity on the lack of pulmonary recovery is not fully understood. The new PET tracer \[68Ga\]FAPI-46 (FAPI) allows for imaging of activated fibroblasts. The aim of this study is to explore the pulmonary fibroblast activity, measured with the FAPI PET/CT, in patients with non-resolving ARDS.
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Patient outcome - ICU stay
Timeframe: From inclusion until the end of the study (28 days after inclusion)
Patient outcome - 28 days mortality
Timeframe: From inclusion until end of the study (28 days after inclusion)
Patient outcome - VFD-28
Timeframe: From inclusion until end of the study (28 days after inclusion)