Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption… (NCT06690294) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Assessing the Impact of Perceptions of Unpredictability on Objective Measures of Food Consumption and Metabolism
United States110 participantsStarted 2026-08-18
Plain-language summary
Background:
Many people in the United States are overweight or obese. This natural history study will look into how life events during childhood can impact eating behaviors and weight gain as adults.
Objective:
To explore how childhood experiences affect adult eating behaviors.
Eligibility:
Healthy people aged 18 to 60 years.
Design:
Participants will have 3 clinic visits.
They will be screened with blood tests. They will answer questions about their alcohol and tobacco use.
At the next visit, participants will undergo these activities:
Parts of their body (such as waist, neck, and thighs) will be measured with a tape.
They will have an imaging scan to find out how much body fat they have.
They will start wearing a device like a wristwatch that measures their physical activity. They will wear this device for up to 10 days.
They will wear a device on their upper arm or belly that measures blood glucose (sugar) levels. Participants will wear this for 7-10 days.
They will answer questions about their education, childhood, and routines.
They will receive a kit to collect a stool sample at home.
At the last visit, participants will have these tests:
Participants will relax and breathe normally while wearing a clear, plastic canopy that fits over their entire head.
Blood samples will be taken before and after participants drink a sugary drink.
Participants will be offered a large selection of foods for lunch. They will eat as much as they want. Then they will answer questions about how they feel about food and themselves.
Who can participate
Age range
18 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Exclusion criteria
-Self-reported history of Cushing's disease, pituitary disorders, or hypo- and hyperthyroidism
-Self-reported history of chronic obstructive pulmonary disease or other lung disease that which would limit ability to follow the protocol (investigator judgment)
-Self-reported history of coronary heart disease, heart failure, arrhythmias, and peripheral artery disease that which would limit ability to follow the protocol (investigator judgment)
-Self-reported history of bariatric surgery
-Including self-reported history of previous history of cerebrovascular accidents, dementia, and neurodegenerative disorders
-Self-reported history of active tuberculosis, HIV, chronic coccidiomycosis or other chronic or acute infections
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This study is still not yet recruiting — do you know when it might open, and whether it would make sense for me to wait for it or focus on something else in the meantime?
2The trial seems to be looking at how a person's sense of unpredictability in life might affect how much they eat and whether they eat when they're not actually hungry — do you think my own eating patterns or stress history could be relevant to whether this kind of research might apply to me?
3Since this study is listed under 'Phase NA,' which suggests it's more of an observational or behavioral study than a drug trial, can you help me understand what would actually be involved — like tests, questionnaires, or monitored meals — and how much time it would take out of my week?
4The study is measuring something called 'eating in the absence of hunger' — is that a pattern you've noticed in my situation, and could participating in research like this give us useful information about my relationship with food?
5If I'm interested in understanding or addressing my eating behaviors, are there established treatments or programs you'd recommend I consider first, rather than waiting for this study to begin recruiting?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
To determine whether an association exists between unpredictability schema measures and ad libitum food intake.
Timeframe: Day 10
2
To determine whether an association exists between the unpredictability schema and experience scores and eating in the absence of hunger
Timeframe: Day 10
Trial details
NCT IDNCT06690294
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)