Trial of the F2 Filter and Delivery System for Embolic Protection During TAVR

Key Inclusion Criteria: * Age ≥ 50 years. * Patient meets the established criteria and indications for commercially available TAVR via transfemoral access and is scheduled to undergo TAVR per their treating physician. * Patient is willing and able to comply with protocol-specified follow-up evaluations. * Patient is able and willing to provide written informed consent. * Patient meets all criteria for use of control device (Sentinel device, per IFU). Key Exclusion Criteria: General Exclusion Criteria: * Patient requires an urgent or emergent TAVR procedure. * Any interventional cardiovascular procedure performed within 30 days prior to TAVR procedure or planned within 30 days post-TAVR procedure. * Diagnostic cardiac catheterization within 10 days prior to TAVR procedure. * Evidence of an acute myocardial infarction within 3 months prior to TAVR procedure. * Prior prosthetic heart valve in any position. * Known intracardiac thrombus. * Active infection or endocarditis. * Patient is contraindicated for anti-platelet and/or anticoagulant therapy. * Patient refuses blood transfusion. * Renal insufficiency (creatinine \> 2.5 mg/dL or GFR \< 30) and/or renal replacement therapy at the time of screening. * Patients with hepatic failure (Child-Pugh class C). * Severe ventricular dysfunction with left ventricular ejection fraction (LVEF) \< 30%. * Females who are pregnant or nursing or plan to become pregnant during their participation in the study. Neurological Exclusion Criter…