E-cigarette Cessation in Adults Who Co-use Cannabis (NCT06688539) | Clinical Trial Compass
RecruitingPhase 4
E-cigarette Cessation in Adults Who Co-use Cannabis
United States105 participantsStarted 2025-02-19
Plain-language summary
The purpose of this study is to better understand tobacco outcomes using a commonly prescribed stop smoking medication (varenicline) and financial incentives for adults who also use cannabis. Varenicline is not FDA approved for e-cigarette cessation, but is FDA approved for cigarette cessation. Investigators are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive e-cigarette cessation treatment for 12 weeks. To qualify, participants must be between the ages of 18-40 and use both e-cigarettes and cannabis. Participants do not need to be interested in quitting cannabis to qualify. This study is being conducted at three sites: the Medical University of South Carolina in Charleston, SC, Behavioral Health Services in Pickens, SC, and MUSC Lancaster in Lancaster, SC.
Who can participate
Age range
18 Years – 40 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Between the ages of 18 and 40 years old
* Use e-cigarettes daily or near daily in the past month
* Must submit a positive instant-read urine cotinine test at screening (≥ 200 ng/ml)
* Be interested in quitting use of e-cigarettes
* Must be willing to take varenicline for the standard 12-week course of treatment
* Self-reported use of cannabis on at least 10 out of the past 30 days or must submit a positive qualitative urinary cannabinoid test at screening (\> 50 ng/ml)
Exclusion Criteria:
* Any serious or unstable medical/psychiatric disorder (including severe substance use disorders, other than cannabis or tobacco use disorders) in the past three months that may interfere with study performance
* Use of cigarettes on 10+ days in the past 30
* Currently pregnant or breastfeeding
* Current use of medications with smoking cessation efficacy
* Use of any medications that would interfere with varenicline
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial is specifically focused on people who use both e-cigarettes and cannabis — does my particular pattern of use make me a good candidate to discuss this study with you?
2Since this is a Phase 4 trial, the treatments being tested have already been approved for safety and effectiveness in the general population — can you help me understand what new information this study is trying to gather about people who co-use cannabis specifically?
3The trial measures whether someone has stopped using tobacco for 7 days by the end of a 12-week treatment period — is a 12-week commitment realistic for my situation, and what happens to my care if I need to stop participating before it ends?
4Are there standard, already-proven approaches to quitting e-cigarettes that I should consider first, or do you think a structured study like this one might actually offer me better support than what's currently available outside a trial?
5Since cannabis use is specifically part of what this trial is studying, would participating mean any changes to how I'm currently using cannabis, and is that something worth thinking through before we decide if this study is worth pursuing?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
7-day point prevalence tobacco abstinence at the end of treatment (Week 12)