Acetylcholinesterase Inhibitor in Anorexia Nervosa: Multicenter, Double-Blind, Placebo-Controlled Trial

Inclusion Criteria: * Female * Presence of the 3 DSM-V criteria for Anorexia Nervosa * Restrictive subtype of Anorexia Nervosa according to DSM-5 * Body Mass Index between 15 and 18.5 kg/m² * Aged 18 to 65 years * Resting heart rate \> or = 40 bpm * Use of a highly effective contraceptive method * Affiliation or entitlement to a Health Insurance scheme * Prior free, informed, and written consent Exclusion Criteria: * Presence of one or more somatic criteria for hospitalization according to french HAS 2010 guidelines * Past diagnosis of anorexia nervosa with binge-eating/purging type * Past diagnosis of bulimia nervosa * Past diagnosis of binge-eating disorder * Associated diagnosis of schizophrenia and/or persistent delusional disorder and/or bipolar disorder * History of asthma or obstructive bronchopulmonary disease * History of peptic ulcer disease or concurrent treatment with non-steroidal anti-inflammatory drugs * History of epileptic disorders * Renal insufficiency (glomerular filtration rate less than 60 mL/min according to the MDRD formula) * Hepatic insufficiency or transaminase levels greater than 5 times the normal upper limit * Conductance disorder characterized by electrocardiogram * QTc according to Bazett's formula greater than 480 ms on electrocardiogram * Current or recent (within three weeks prior to inclusion) psychotropic treatment (including antidepressants, to avoid interaction/potentiation in this population) * Treatment involving the following cy…