CompletedNot Applicable

Nasal High Frequency in Preterm Neonates

Egypt90 participantsStarted 2021-07-15

Plain-language summary

One of the most commonly used non-invasive methods is nasal continuous positive airway pressure (nCPAP). Although high frequency ventilation (HFV) has been applied in many neonatal intensive care units, nasal high frequency oscillatory ventilation (nHFOV) is a relatively new non-invasive modality. The application of nasal high-frequency ventilation with the strategy of lung recruitment will combine benefits of improving gas exchange and decreasing lung injury together with avoiding complication of invasive ventilation.

Who can participate

Age range1 Day – 28 Days

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Gestational age: 30-34 weeks (determined by date of last menstrual period or ultrasound) and confirmed by Ballard score. * Recruited immediately after birth Up to 24 hours of age. * Appropriate weight for the gestational age. * Spontaneous breathing and clinical signs and symptoms of respiratory distress syndrome (grunting, cyanosis, intercostal and subcostal retractions) or RDS Silverman Score \> 5. Exclusion Criteria: * Major congenital abnormalities, congenital heart disease and diaphragmatic hernia. * A need for intubation and mandatory ventilation during resuscitation or on the first day of life. * Perinatal asphyxia (Umbilical cord pH \< 7.16, and umbilical cord bicarbonate \< 12 mEq/L) * Pulmonary hemorrhage and severe intraventricular hemorrhage (IVH) on admission.

What they're measuring

need for invasive mechanical ventilation

Timeframe: five days

Trial details

NCT IDNCT06687083

SponsorAin Shams University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-07-15

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