CompletedNot Applicable

Bioavailability Trial

United Kingdom8 participantsStarted 2022-08-01

Plain-language summary

Carrot is a unique vegetable owing to the availability of bioactive compounds polyacetylenes (PA) as well as carotenoids present in it. These compounds have been shown to be associated with reduced cancer risk in epidemiological-based studies, and also showed anticancer properties in vitro studies and in vivo in mouse and rat models. To investigate whether the PA and carotenoids could have beneficial effects in humans, the present study is designed to determine whether they are detectible in human biofluids after the ingestion of a portion of carrots and whether there is a difference in the magnitude of detection after eating a large (300g) and normal (100g) portion.

Who can participate

Age range

20 Years – 50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * Healthy adults 20+ years old. * Having body mass index (BMI) between ≥18.5 - ≤30 kg/m2. * Must be willing to eat a portion (100g) of carrot in the test session 1, alongside 2 slices of bread with 10g butter. * Must be willing to eat a portion (300g) of carrot in the test session 2, alongside 2 slices of bread with 10g butter. Exclusion Criteria: * Having any metabolic or gastrointestinal conditions. * Having allergies to carrot or bread or butter. * Taking any medication that affects metabolism or digestion. * Smokers.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Absorption of PA and carotenoids

Timeframe: 48hr

Trial details

NCT IDNCT06686004

SponsorNewcastle University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-08-10

View on ClinicalTrials.gov More Absorption, Metabolism and Excretion in Healthy Volunteers trials