CompletedNot Applicable

Bioavailability Trial

United Kingdom8 participantsStarted 2022-08-01

Plain-language summary

Carrot is a unique vegetable owing to the availability of bioactive compounds polyacetylenes (PA) as well as carotenoids present in it. These compounds have been shown to be associated with reduced cancer risk in epidemiological-based studies, and also showed anticancer properties in vitro studies and in vivo in mouse and rat models. To investigate whether the PA and carotenoids could have beneficial effects in humans, the present study is designed to determine whether they are detectible in human biofluids after the ingestion of a portion of carrots and whether there is a difference in the magnitude of detection after eating a large (300g) and normal (100g) portion.

Who can participate

Age range20 Years – 50 Years

SexALL

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Inclusion criteria: * Healthy adults 20+ years old. * Having body mass index (BMI) between ≥18.5 - ≤30 kg/m2. * Must be willing to eat a portion (100g) of carrot in the test session 1, alongside 2 slices of bread with 10g butter. * Must be willing to eat a portion (300g) of carrot in the test session 2, alongside 2 slices of bread with 10g butter. Exclusion Criteria: * Having any metabolic or gastrointestinal conditions. * Having allergies to carrot or bread or butter. * Taking any medication that affects metabolism or digestion. * Smokers.

What they're measuring

Absorption of PA and carotenoids

Timeframe: 48hr

Trial details

NCT IDNCT06686004

SponsorNewcastle University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-08-10

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