RecruitingNot Applicable

Explore the Effects of Cortical Priming on Visuomotor Stepping Learning in Persons With Chronic Stroke

United States108 participantsStarted 2025-04-23

Plain-language summary

This research study aims to understand the relationship between brain stimulation and leg skill learning in both healthy adults and persons with chronic stroke.

Who can participate

Age range21 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age between 21 and 90 years
✓. Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment
✓. MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract
✓. Hemiparesis involving the lower extremity (Fulg-Meyer LE motor test)
✓. No passive range of motion limitation in bilateral hips and knees
✓. Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less
✓. Visual acuity can be corrected by glasses or contact lens to 20/20
✓. Able to walk independently with/without assistant devices for 10 meters

Exclusion criteria

✕. Pregnant women
✕. MRI or CT evidence of involvement of the basal ganglia or cerebellum, evidence of multiple lesions, or evidence of any other brain damage or malignant neoplasm or tumors
✕. Have any metal implants, cardiac pacemakers, or history of seizures
✕. Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training
✕. Any vestibular dysfunction or unstable angina
✕. Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia\*

What they're measuring

Mean change from baseline in stepping motor control after five sessions of brain stimulation combined with visuomotor stepping learning

Timeframe: Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training

Mean change from baseline in brain neuronal activations after five sessions of brain stimulation combined with visuomotor stepping learning

Timeframe: Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training

Trial details

NCT IDNCT06681207

SponsorThe University of Texas Medical Branch, Galveston

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08-30

Contact for this trial

Shih-Chiao Tseng, PT, PhD

409--772-9555 shtseng@utmb.edu

View on ClinicalTrials.gov More Stroke trials

Who can participate

Age range21 Years – 90 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age between 21 and 90 years
✓. Medical history of a unilateral stroke occurring ≥ 6 months prior to enrollment
✓. MRI or CT evidence from the imaging report shown that the stroke involves the corticospinal tract
✓. Hemiparesis involving the lower extremity (Fulg-Meyer LE motor test)
✓. No passive range of motion limitation in bilateral hips and knees
✓. Limitation of ankle passive range of motion to 10 degrees of dorsiflexion or less
✓. Visual acuity can be corrected by glasses or contact lens to 20/20
✓. Able to walk independently with/without assistant devices for 10 meters

Exclusion criteria

✕. Pregnant women
✕. MRI or CT evidence of involvement of the basal ganglia or cerebellum, evidence of multiple lesions, or evidence of any other brain damage or malignant neoplasm or tumors
✕. Have any metal implants, cardiac pacemakers, or history of seizures
✕. Ongoing orthopedic or other neuromuscular disorders that will restrict exercise training
✕. Any vestibular dysfunction or unstable angina
✕. Significant cognitive deficits (inability to follow a 2-step command) or severe receptive or global aphasia\*

What they're measuring

Mean change from baseline in stepping motor control after five sessions of brain stimulation combined with visuomotor stepping learning

Timeframe: Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training

Mean change from baseline in brain neuronal activations after five sessions of brain stimulation combined with visuomotor stepping learning

Timeframe: Day 1, Day 5, Day 7, Day 30, Day 60, Day 9 post five sessions of brain stimulation combined with visuomotor stepping training