Silver Nitrate vs. Triamcinolone for Treatment of Hypergranulation Tissue (NCT06681194) | Clinical Trial Compass
WithdrawnPhase 2/3
Silver Nitrate vs. Triamcinolone for Treatment of Hypergranulation Tissue
Stopped: No subjects recruited at this time
United States0Started 2025-03-01
Plain-language summary
This randomized controlled trial aims to compare the efficacy of silver nitrate, triamcinolone, and a successive use of both treatments in managing hypergranulation tissue in traumatic wounds. Conducted over a four-year period at UPMC Mercy, the study will involve patients presenting with hypergranulation tissue. Participants will be randomly assigned to receive either topical silver nitrate, topical triamcinolone, or a combination of the two in succession. The study will assess treatment outcomes based on the reduction or resolution of hypergranulation tissue, with the goal of identifying the most effective therapeutic approach. This research will provide valuable insights into optimizing treatment strategies for hypergranulation tissue in traumatic wounds.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients must be 18 years or older.
* Patients must be admitted to the institution with non-infected, traumatic wounds exhibiting hypergranulation tissue.
* Patients must provide consent to participate in the study.
* Eligible wounds include superficial or partial-thickness wounds.
* Wounds will be categorized based on size and depth, with variations controlled for in the statistical analysis.
Exclusion Criteria:
* Patients with known allergies or contraindications to silver nitrate or triamcinolone.
* Patients with wounds that do not exhibit hypergranulation tissue.
* Patients with wounds not primarily due to traumatic injury (e.g., surgical wounds, pressure ulcers).
* Full-thickness, infected, or complex wounds will be excluded, as these may require different management strategies.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Reduction in Hypergranulation Tissue Size
Timeframe: From enrollment to 1 year after resolution of hypergranulation
2
Vancouver Scar Scale (VSS)
Timeframe: From enrollment to 1 year after resolution of hypergranulation
3
Time to healing
Timeframe: From enrollment to 1 year after resolution of hypergranulation
4
Patient and Observer Scar Assessment Scale (POSAS)
Timeframe: From enrollment to 1 year after resolution of hypergranulation