Current research on early intestinal development is primarily performed in mouse models. While useful in many other ways, mouse models are not ideal for studying human intestine development as the timing of this process differs between the two species. Further, prior research has demonstrated that some proteins and pathways that are critical in human development have no clear role in mice. This study aims to improve the overall understanding of critical aspects of intestinal development in humans. In addition, this study will investigate the impact of intestinal diseases that are found in the early stages of life such as necrotizing enterocolitis (NEC).
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Number of intestinal stem cells and mature epithelial cells
Timeframe: At the time of surgery for another clinical problem.
Degree of Immune System Changes
Timeframe: Within 48 hours before or after the clinically-driven surgery.
Fraction of Stool Microbiome that has beneficial microbes
Timeframe: Within 48 hours before or after the surgery from which the biopsy is obtained.