RecruitingPhase 2

ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis

United States20 participantsStarted 2025-02-25

Plain-language summary

The goal of this clinical trial is to see if adding abatacept to tacrolimus and MMF prevents or reduces the chances of acute graft versus host disease which is a complication that can occur after transplant in participants with blood cancer. The usual therapy for graft versus host disease prevention after a cord blood transplant includes tacrolimus and MMF. The main question this clinical trial aims to answer is whether or not abatacept will be safe and effective in reducing aGVHD rates in dCBT. Participants will: * Partake in exams, tests, and procedures as part of usual cancer care. * Partake in conditioning, which is the treatment that is given before a transplant. * Have a cord blood transplant. * Partake in radiation following the transplant.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with the following hematologic malignancies: * Acute myelogenous leukemia (AML): High-risk and intermediate-risk AML including: * Antecedent hematological disease (e.g., myelodysplasia (MDS)) * Treatment-related leukemia * Complete Remission (CR1) with poor or intermediate-risk cytogenetics or molecular markers (e.g. Flt 3 mutation, 11q23, del 5, del 7, complex cytogenetics) * CR2 or CR3 * Induction failure or 1st relapse with \< 10% blasts in the marrow * Acute lymphoblastic leukemia (ALL): * High-risk CR1 including: * Poor-risk cytogenetics (e.g., Philadelphia chromosome t(9;22)or 11q23 rearrangements) * Philadelphia chromosome-like ALL * Presence of minimal disease by flow cytometry after 2 or more cycles of chemotherapy * No CR within 4 weeks of initial treatment * Induction failure with \< 10% blasts in the marrow * CR2 or CR3 * Myelodysplastic syndromes (MDS), Intermediate, High or Very High Risk by the revised international prognostic scoring system or treatment related MDS. * Bi-phenotypic or mixed-phenotypic acute leukemia in: * CR. * Induction failure or 1st relapse with \< 10% blasts in the marrow. * Chronic Myelogenous Leukemia (CML) in second chronic phase after accelerated or blast crisis. * Chronic Myelomonocytic Leukemia (CMML) * Hodgkin's Lymphoma that is relapsed or refractory * Age \> or equal to 18 years, \< or equal to 70yrs * KPS \> or equal t…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Severe aGVHD free survival

Timeframe: 180 days after treatment

Trial details

NCT IDNCT06680661

SponsorLeland Metheny

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-10-29

Contact for this trial

Leland Metheny, MD

216-844-0139 Leland.Metheny@uhhospitals.org

View on ClinicalTrials.gov More Acute Myelogenous Leukemia trials