CompletedEarly Phase 1

Hyperbaric Prilocaine 2% vs Hyperbaric Bupivacaine 0.5% in Caesarean Section

Egypt142 participantsStarted 2024-10-09

Plain-language summary

Comparison between effects of hyperbaric bupivacaine 0.5% vs Hyperbaric prilocaine 2% in spinal anesthesia of women undergoing elective caesarean section such as onset time of sensory and motor block, duration of sensory and motor block, effects of maternal hemodynamics and expected side effects .

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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Inclusion criteria

✓. Women aged 18-45 years.
✓. Patients with uncomplicated pregnancies.
✓. American society of anesthesiologist (ASA) physical status I or II.
✓. Height between 155 cm and 175 cm.
✓. Written informed consent provided. -

Exclusion criteria

✕. Patients with known allergies to local anesthetics.
✕. Contraindications to intrathecal anesthesia (e.g., infection at the injection site and coagulopathy).
✕. Severe preeclampsia or eclampsia.
✕. Presence of significant comorbidities (e.g., uncontrolled diabetes, hypertension, renal or hepatic dysfunction).
✕. History of spinal surgery or significant spinal deformity.
✕. Patients who refuse to participate in the study -

What they're measuring

Measurment of onset time and duration of sensory block of Hyperbaric Bupivacaine 0.5% and Hyperbaric Prilocaine 2% using pinprick sensation test in women undergoing caesarean section

Timeframe: 12 HOURS

2- Measurment of onset time and duration of motor block of Hyperbaric Bupivacaine 0.5% and Hyperbaric Prilocaine 2% using modified bromage scale in women undergoing caesarean section

Timeframe: 12 hours

Trial details

NCT IDNCT06680167

SponsorSohag University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-05

View on ClinicalTrials.gov More Spinal Anesthesia trials