CompletedNot Applicable

Induction and Stabilization of Gamma Oscillations With 40 Hz External Brain Stimulation

Germany30 participantsStarted 2021-07-13

Plain-language summary

The goal of the present studies is to develop and validate novel stimulation protocols for the entrainment of gamma oscillations, which are associated with many cognitive functions and critically involved in cognitive impairment such as Alzheimer's disease. In this proposal, combination of repetitive transcranial magnetic stimulation (rTMS) and transcranial alternating current stimulation (tACS), which has been shown effective for the induction, and stabilisation of alpha and theta frequencies in our forgoing studies, will be adopted to the gamma frequency range and applied on prefrontal regions as well as model-based cortical areas to enhance and stabilize gamma oscillations, thereby facilitating cognition

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * normal or corrected to normal eye vision * right-handed * non-smokers * being 18-60 years old * providing written informed consent Exclusion Criteria: * history of neurological or psychiatric disorders including seizures or epilepsy, * Taking CNS medication * having metal implants * current pregnancy

What they're measuring

Working Memory behavioral performance

Timeframe: During procedure (20 minutes)

electroencephalogram (EEG) oscillatory power

Timeframe: up to 2 hours after the intervention

electroencephalogram (EEG) functional connectivity

Timeframe: up to 2 hours after the intervention

Trial details

NCT IDNCT06680154

SponsorThe National Brain Mapping Laboratory (NBML)

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-11-30

View on ClinicalTrials.gov More Alzheimer Disease trials