SMART-r: Substance Monitoring and Active Relapse Tracking Repository (NCT06676059) | Clinical Trial Compass
RecruitingNot Applicable
SMART-r: Substance Monitoring and Active Relapse Tracking Repository
United States10,000 participantsStarted 2026-07-02
Plain-language summary
Background:
About 1.5 million adults in the US enter alcohol or substance use treatment programs each year. Unfortunately, more than half of patients do not finish their program. For those who start treatment, about 70% return to substance use within weeks or months after starting treatment. To discover why patients drop out of treatment and return to substance use - and what can be done about it - researchers need to learn more about people who use drugs and alcohol.
Objective:
To create a data repository by gathering survey and smartphone data from adults who use drugs and alcohol in order to conduct future research.
Eligibility:
Adults who have used drugs or alcohol in the past and have a Android smartphone. The researchers will recruit targeted demographics at different times throughout the duration of the study period.
Design:
Data will be collected for up to 6 months. All research activities will be online.
Participants will download a smartphone app called TTRU-Curtis AWARE and keep it active on their phone. The app will run in the background and collect participant data, including: screen unlocks, duration of time the screen is on; apps used; words typed (except passwords); duration and time of phone calls; estimated location (exact location is not collected); and movement, such as how many steps are taken in a day. All personally identifying information is automatically removed before the data is stored (including phone numbers, names, or locations described in messages).
Each day, participants will receive a text with a link to a survey. They will answer questions about their mood, behavior, and substance use from the day before. This survey should take less than 5 minutes to complete.
Every 30 days, participants will complete a longer survey. They will answer questions about their personal relationships, risky behaviors, mood, substance use, and feelings. They can skip any questions they do not feel comfortable answering. These surveys should take about 30 minutes to complete.
Participants may opt to allow researchers to access their social media posts.
Who can participate
Age range
18 Years – 120 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
* INCLUSION CRITERIA:
In order to be eligible to participate in the repository, an individual must meet all of the following criteria:
* Must understand and be willing to complete an online informed consent process.
* Be an adult aged 18 or older.
* Self-report alcohol or other drug use within the past 30 days.
* Have a smartphone as their primary mobile phone.
* Be willing to adhere to the procedures, such as downloading the AWARE app onto their smartphone and keeping it active throughout the data collection period, completing baseline questionnaires, daily diary EMAs, uploading historical conversational AI data, and/or follow-up surveys.
* Understand and write in English.
--This exclusion criterion is included because future research on the data collected will include linguistic analysis. all linguistic analyses, we remove rare words (e.g., words must be said by at least 95% of participants)95. Additionally, there are cultural differences across languages and, thus, interpreting language results across more than one language becomes difficult.96 As a result, we must keep analysis limited to a single language (English), since words in other languages will not meet that criteria.
* Live in the United States.
EXCLUSION CRITERIA:
An individual who meets any of the following criteria will be excluded from participation in this repository:
1\. Any impairment severe enough to preclude informed consent or valid self-report.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial seems to focus on collecting data about substance use and relapse patterns rather than testing a new treatment — does that mean joining it wouldn't change or replace any active treatment I'm currently receiving or being offered?
2Since this study is categorized as 'NA' for phase, it appears to be a data repository rather than a drug or therapy trial — can you help me understand exactly what would be monitored, how my information would be stored, and who would have access to it?
3Given that the primary goal is building a data repository called 'SMARTr,' what would actually be required of me in terms of time, check-ins, or reporting — and would that realistically fit into my current situation?
4Before I consider joining a research repository like this, are there active treatment trials or standard-of-care options for alcohol use or substance use disorder that I should be pursuing at the same time or instead?
5How would my participation in this data collection study benefit my own care, or is the main benefit to future patients and research — and is that something worth discussing in terms of what's right for me right now?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.