CompletedPhase 2

The Proposed Study Aims to Investigate the Impact of Adjunctive Vitamin D Gel Application on Gingival Crevicular Fluid Levels of Alkaline Phosphatase and Interleukin-8 in Periodontitis Patients Undergoing Phase 1 Periodontal Therapy. By Elucidating the Molecular Mechanisms Underlying the Therapeutic

Egypt50 participantsStarted 2023-09-01

Plain-language summary

The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.

Who can participate

Age range25 Years – 55 Years

SexALL

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Inclusion Criteria: * Patients with attachment loss 3-4 mm * periodontal pocket ≤ 5 mm Exclusion Criteria: * \- Patients with sensitivity to the medication used in the study. * Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study. * Patients with systemic diseases. * Pregnant and lactating females. * Smokers and tobacco chewers. * Patients not compliant with oral hygiene procedures.

What they're measuring

Periodontal Assessment

Timeframe: 12 weeks

Trial details

NCT IDNCT06669026

SponsorMansoura University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-03-15

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