Effects of n3 LC PUFAs on Inflammatory, Immune and Senescence Features in Polyvascular Older Subjects (OMSAGE)

Inclusion Criteria: * ≥ 75 years old * Patients with polyvascular disease in cases of vascular lesions in ≥2 disease territories or any combination of coronary, peripheral, or carotid artery disease. * Able to comply with the requirements of the study protocol * Signed informed consent form approved by the ethical committee * No illness or event within 2 months prior to inclusion (hospitalization, trauma, active cancer, infection, acute failure of chronic disease, surgical intervention) * No history of multiple and/or severe allergies to drugs or foods * No consumption of fish oil or omega-3 fatty acid supplements within 2 months prior to inclusion * No consumption of more than 500 mg/day of dietary omega-3 fatty acids (questionnaire) * No intake of anti-inflammatory or corticosteroid medication within 2 weeks prior to inclusion * Able and authorized to take a pill * No intervention planned in the months following the start of the study Exclusion Criteria: * Inflammatory syndrome (CRP \>10 mg/l) on day 0 and day 7 * Acute illness or event during the time of intervention