CompletedNot Applicable

Resistance Exercise in Severe Knee Osteoarthritis

Spain28 participantsStarted 2023-04-10

Plain-language summary

This study aim to evaluate pain after different resistance training protocols (placebo, 4 sets of 10RM, 8 sets of 10 RM and 12 sets of 10RM) in patients with severe knee osteoarthritis.

Who can participate

Age range

55 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * men and women at least 55 years old * diagnosed with severe knee OA * scheduled for unilateral Total Knee Arthroplasty (TKA) surgery Exclusion Criteria: * pain in the contralateral (non-studied) limb (maximum ≥80 of 100 mm on a visual analog scale (VAS) during daily activities) * another hip or knee joint replacement in the previous year * any medical condition in which exercise was contraindicated * participated in exercise programs (\>2 days/week, training at intensities of 10-15RM) in the 6 months prior to the study * history of stroke, brain surgery, major depression, or any self-perceived cognitive alterations that could affect the performance of study tasks

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in self-reported pain intensity

Timeframe: Pre-exercise (pre), immediate post exercise (post), and 10 min after exercise (post 10min)

Change in pressure pain thresholds

Timeframe: Pre-exercise (pre), immediate post exercise (post), and 10 min after exercise (post 10min)

Trial details

NCT IDNCT06664905

SponsorUniversity of Valencia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-05-10

View on ClinicalTrials.gov More Knee Osteoarthritis trials

Who can participate

Age range

55 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.