CompletedNot Applicable

Alpha-lipoic Acid in Critically Ill Patients With Sepsis

Egypt80 participantsStarted 2024-10-15

Plain-language summary

Evaluate the of effect of alpha-lipoic acid in critically ill septic patients. 80 septic patients will be enrolled from Damanhur National medical institute, and they will be randomized using simple randomization into control group will receive placebo and ALA group will be given 1800 mg orally or via a nasogastric tube of ALA daily for seven days .

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who will be diagnosed with sepsis or develop sepsis during their ICU length of stay * Age 18 year and older * Patient able to receive oral or enteral medication Exclusion Criteria: * Patients who will be diagnosed with septic shock * Female patients who are pregnant or lactating. * Participation in another clinical trial. * Current treatment with other medications that have antioxidant effects, such as vitamin C and vitamin E. * Allergy to LA or similar active agents (e.g., vitamin B), or previous intolerance to the recommended dose of LA

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Sequential Organ Failure Assessment (SOFA) Score

Timeframe: 1 week

CRP (mg/L)

Timeframe: 1 Week

Syndecan 1 (ng/mL)

Timeframe: 1 Week

IL-6 (pg/mL)

Timeframe: 1 Week

Trial details

NCT IDNCT06661993

SponsorDamanhour University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-28

View on ClinicalTrials.gov More Sepsis trials

Plain-language summary

Who can participate

Age range

18 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.