CompletedNot Applicable

Alpha-lipoic Acid in Critically Ill Patients With Sepsis

Egypt80 participantsStarted 2024-10-15

Plain-language summary

Evaluate the of effect of alpha-lipoic acid in critically ill septic patients. 80 septic patients will be enrolled from Damanhur National medical institute, and they will be randomized using simple randomization into control group will receive placebo and ALA group will be given 1800 mg orally or via a nasogastric tube of ALA daily for seven days .

Who can participate

Age range18 Years – 80 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients who will be diagnosed with sepsis or develop sepsis during their ICU length of stay * Age 18 year and older * Patient able to receive oral or enteral medication Exclusion Criteria: * Patients who will be diagnosed with septic shock * Female patients who are pregnant or lactating. * Participation in another clinical trial. * Current treatment with other medications that have antioxidant effects, such as vitamin C and vitamin E. * Allergy to LA or similar active agents (e.g., vitamin B), or previous intolerance to the recommended dose of LA

What they're measuring

Sequential Organ Failure Assessment (SOFA) Score

Timeframe: 1 week

CRP (mg/L)

Timeframe: 1 Week

Syndecan 1 (ng/mL)

Timeframe: 1 Week

IL-6 (pg/mL)

Timeframe: 1 Week

Trial details

NCT IDNCT06661993

SponsorDamanhour University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-10-28

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