CompletedPhase 2/3

EFFECTIVENESS of PROBIOTICS in ADULTS with MODERATE to SEVERE PERSISTENT ASTHMA

Pakistan74 participantsStarted 2021-12-06

Plain-language summary

The objective of this study is to compare the effectiveness of probiotic as an adjuvant to standard therapy versus standard therapy alone in adult with moderate to severe persistent asthma in terms of 1. Frequency of asthma exacerbations in terms of number of asthma attacks and severity of each episode. 2. Improvement in pulmonary function tests as recorded by an increase in FEV1 and FEV1/FVC ratio. 5\. HYPOTHESIS Probiotics as an adjuvant to standard therapy is more effective as compared to the standard therapy alone in managing moderate to severe persistent bronchial asthma.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Patient of both genders between the ages of 18 and 80 years.
✓. Diagnosed cases of moderate to severe persistent asthma, as determined by ACT Score and FEV1/FVC ratio as per operational definition.

Exclusion criteria

✕. Patients with Mild asthma.
✕. Pregnant females.
✕. Patients who have taken fiber supplements or probiotics during the last four weeks.
✕. Other pulmonary disorders, such as Churg-Strauss syndrome, allergic bronchopulmonary aspergillosis (ABPA), chest wall deformities, bronchiectasis, pulmonary fibrosis, and lung cancer.
✕. Asthma and chronic obstructive pulmonary disease overlap syndrome (ACOS).

What they're measuring

Frequencies of exacerbation

Timeframe: 3 months

Trial details

NCT IDNCT06657066

SponsorKing Edward Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-04-24

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