Not Yet RecruitingNot Applicable

Immunogenomic Analyses of Pediatric Catatonia

120 participantsStarted 2024-12-01

Plain-language summary

Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 40 children and adolescents who are admitted to Rady Children's Hospital San Diego with a catatonia diagnosis. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve the ability to identify the cause of catatonia and impact care. The investigator also hopes to identify new genetic and/or autoimmune causes of catatonia that may inform new treatment for future patients.

Who can participate

Age range0 Years – 17 Years

SexALL

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Inclusion criteria

✓. Child/adolescent Ages 0-17 (2) with a diagnosis of catatonia.
✓. Biological parents of child/adolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed to be genetically related to a patient participant

Exclusion criteria

✕. Already received any prior whole genome sequencing or exome sequencing.
✕. Unable to approach the family or patient for enrollment.
✕. Unable to obtain informed consent.
✕. Family members are ineligible for participation in this study if:
✕. They are known to not be genetically related to the child/adolescent patient participant

What they're measuring

Diagnostic rate of whole genome sequencing

Timeframe: 2 years

Diagnostic rate of brain reactive autoantibodies

Timeframe: 2 years

Trial details

NCT IDNCT06656572

SponsorRady Pediatric Genomics & Systems Medicine Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09-01

Contact for this trial

Aaron Besterman, MD

858-576-1700 abesterman@health.ucsd.edu

View on ClinicalTrials.gov More Catatonia trials