"The Effect of Trimetazidine on the Clinical Outcome of Acute Ischemic Stroke Patients"

Inclusion Criteria: * Adult patients (≥18 years old) admitted to the stroke unit with a diagnosis of acute ischemic stroke by CT scan after excluding hemorrhagic stroke * Patients with an NIHSS score between 5 and 25 * Within 6 - 12 hours from the initial symptoms presentation. Exclusion Criteria: * Thrombolysis-eligible patients * Patients already on Trimetazidine for any other indication * Patients who are NPO * Patients with impaired liver function are defined as INR of 1.5 or higher, elevated AST and ALT more than 3 times the upper normal limit, thrombocytopenia with platelets, 150, 000 in a patient without cirrhosis or preexisting liver disease. * Patients with inadequate renal function defined as creatinine clearance of 60 mls/min or less * Pregnancy and lactation * Contraindications of trimetazidine such as hypersensitivity to TMZ, Parkinson's disease, tremors, restless leg syndrome, or other movement disorders