Supplemental Postoperative Bupivacaine Following Non-Surgical Endodontic Treatment
United States150 participantsStarted 2024-11-01
Plain-language summary
The study will investigate the impact of an additional injection of long-acting anesthetic on pain level, quality of life, and use of pain medication after a nonsurgical endodontic treatment. The long-acting anesthetic will be compared to a mock injection group and a group with no additional anesthetic to determine any differences in effects.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Medical ASA Class I or II
✓. Patients above 18 years old
✓. Patients with a blood pressure below 160/100
✓. Patients who are treatment planned and have agreed to have emergency endodontic therapy or non-surgical root canal therapy with a pulpal diagnosis of symptomatic irreversible pulpitis according to the AAE Glossary of Endodontic Terms.
✓. Patients must be able to comprehend and complete all study protocols, written consent, and questionnaires in English.
Exclusion criteria
✕. Medical ASA III or above
✕. Patients who reported the use of tobacco or nicotine-containing products such as vapes, e-cigarettes, gums, or pouches and will not in the 48 hours following treatment
✕. Patients who reported the use of any marijuana products or illicit drugs in the 48 hours prior to treatment and will not in the next 48 hours.
✕. Patients who have taken opioids to control pain.
✕. Pregnant patients
✕. Patients with a blood pressure of 160/100 or greater
✕. Patients with a known hypersensitivity or allergy to any local anesthetic agent of the amide group, or any other components of the two anesthetic solutions such as epinephrine, sodium metabisulfite used in the study.
What they're measuring
1
Quality of life (scored based on the OHIP-14 questionnaire)
Timeframe: Day of operation and daily for four days immediately following endodontic treatment