Not Yet RecruitingEarly Phase 1

Pharmacokinetics of Oral Calcium Carbonate in Parturients

United States60 participantsStarted 2025-01

Plain-language summary

This study investigates the time course of change in calcium in the blood after a pregnant subject takes an oral dose of calcium carbonate (commonly marketed as "Tums"). This information is important for trials investigating whether calcium can reduce postpartum hemorrhage, bleeding after delivery.

Who can participate

Age range18 Years – 45 Years

SexFEMALE

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Exclusion criteria

✕. severe range blood pressure (BP \>160/\>110) within the 48 hours prior to delivery
✕. patient age \<18 years or \>45 years
✕. renal dysfunction with a documented serum Cr \> 1.0 mg/dL
✕. known history of congenital or acquired cardiac disease or history of arrhythmia
✕. patient taking digoxin
✕. patient currently taking a calcium channel blocker
✕. Weight \<55kg or \>100kg, or
✕. receiving magnesium infusion within 24 hours prior to or during cesarean delivery

What they're measuring

Ionized calcium concentration

Timeframe: 4 hours

Trial details

NCT IDNCT06650930

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08

Contact for this trial

Jessica R Ansari, MD, MS

650-723-4000 jansari@stanford.edu

View on ClinicalTrials.gov More Pregnancy trials