RecruitingNot Applicable

DEliriuM in STroke: the Link Between Stroke, Delirium and Long-term Cognitive Impairment

Belgium150 participantsStarted 2024-05-20

Plain-language summary

Primary objective of this study: determine whether PSD is a risk factor for PSCI, independent of brain frailty and premorbid cognitive functioning. Secondary objectives: 1. to investigate the role of infarct location, imaging markers of brain frailty and brain network disintegration in the development of PSD; 2. to investigate the role of persistent brain network disintegration in the development of PSCI.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18 years or older, * clinical diagnosis of first-ever ischemic stroke (onset \<72h at time of inclusion), * admitted at stroke unit of UZ Brussel, * ability to participate in cognitive assessments, * fluency in Dutch or French, * ability to undergo an EEG during the first 24 hours after onset of stroke symptoms, * ability to undergo MRI of the brain. Exclusion Criteria: * epilepsy history, * pre-existing, space occupying brain lesion (except small meningeoma), * pregnancy or wish to become pregnant, * severe language impairment or dementia impeding cognitive assessment, life expectancy of less than 1 year.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Post-stroke delirium

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the alfa frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the beta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the delta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the theta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the peak frequency band

Timeframe: first 72 hours after stroke symptom onset

Trial details

NCT IDNCT06650436

SponsorUniversitair Ziekenhuis Brussel

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-05

Contact for this trial

Fenne Vandervorst, MD

024776801 fenne.vandervorst@uzbrussel.be

View on ClinicalTrials.gov More Ischemic Stroke trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Post-stroke delirium

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the alfa frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the beta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the delta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the theta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the peak frequency band

Timeframe: first 72 hours after stroke symptom onset