RecruitingNot Applicable

DEliriuM in STroke: the Link Between Stroke, Delirium and Long-term Cognitive Impairment

Belgium150 participantsStarted 2024-05-20

Plain-language summary

Primary objective of this study: determine whether PSD is a risk factor for PSCI, independent of brain frailty and premorbid cognitive functioning. Secondary objectives: 1. to investigate the role of infarct location, imaging markers of brain frailty and brain network disintegration in the development of PSD; 2. to investigate the role of persistent brain network disintegration in the development of PSCI.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18 years or older, * clinical diagnosis of first-ever ischemic stroke (onset \<72h at time of inclusion), * admitted at stroke unit of UZ Brussel, * ability to participate in cognitive assessments, * fluency in Dutch or French, * ability to undergo an EEG during the first 24 hours after onset of stroke symptoms, * ability to undergo MRI of the brain. Exclusion Criteria: * epilepsy history, * pre-existing, space occupying brain lesion (except small meningeoma), * pregnancy or wish to become pregnant, * severe language impairment or dementia impeding cognitive assessment, life expectancy of less than 1 year.

What they're measuring

Post-stroke delirium

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the alfa frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the beta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the delta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the theta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the peak frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the phase lag index (PLI)

Trial details

NCT IDNCT06650436

SponsorUniversitair Ziekenhuis Brussel

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-05

Contact for this trial

Fenne Vandervorst, MD

024776801 fenne.vandervorst@uzbrussel.be

View on ClinicalTrials.gov More Ischemic Stroke trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Post-stroke delirium

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the alfa frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the beta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the delta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the theta frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the relative power in the peak frequency band

Timeframe: first 72 hours after stroke symptom onset

The role of brain network disintegration in post-stroke delirium: electrical analysis of the phase lag index (PLI)