Not Yet RecruitingNot Applicable

The Effect of Short-term Bed Rest on Cardiac Function Measured by Cardiac Magnetic Resonance Imaging

Denmark19 participantsStarted 2024-10-15

Plain-language summary

The primary objective of this study is to investigate the effect of short-term bed rest (4 hours) on heart function, measured by cardiac magnetic resonance (CMR), in healthy participants. This aim will be addressed through a single-arm repeated study, assessing participants during three hours of bedrest. The hypothesis is that short-term bed rest will decrease cardiac output measured by repeated CMR scans. This study will also investigate the reproducibility of CMR within a narrow time frame. Limited data are available on these aspects, despite their critical importance for conducting consecutive examinations, both in clinical practice and research trials10-12. The study also aims to investigate the appliances of short-time measures of cardiac function.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: Male or female. * Age between 18-80 years old. * No use of medications with influence on heart function. * For ethical reasons, we only include participants who are willing to be informed on new health information, as CMR may reveal relevant secondary health findings. Exclusion Criteria: * Diabetes, kidney, or liver disease. * Contraindications to CMR, e.g., abdominal height exceed limitations of the MR-scanner, pacemaker, aortastent, neurostimulator, or other electronic device implanted, implanted metal devices, severe claustrophobia, or physiological diseases. * Pregnant, lactating, or planning to become pregnant within the study period. * In ongoing cancer treatment. * Blood donation during and \< 1 month prior to study. * Simultaneous participation in other clinical trials potentially affecting the study outcome. * Inability, physically or mentally, to comply with the procedure required by the study protocol ad evaluated by the primary investigator, study manager or clinical responsible.

What they're measuring

cardiac output

Timeframe: 0-4 hours

Trial details

NCT IDNCT06644872

SponsorUniversity of Copenhagen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-05-31

Contact for this trial

Bente Kiens, D Sci, PhD

+4528751619 bkiens@nexs.ku.dk