PKP2-ACM Natural History Study

Exclusion criteria

• ✕. Male or female age 12 years or older at the time of providing informed consent (i.e., ICF provision).
• ✕. Capable and willing to provide signed informed consent and/or assent, which includes compliance with the requirements and restrictions listed in the ICF and protocol.
• ✕. Clinical diagnosis of arrhythmogenic cardio myopathy (ACM)
• ✕. Documentation of a pathogenic or likely pathogenic variant in PKP2 by a CLIA-certified genetic testing laboratory
• ✕. History of ICD implantation ≥6 months prior to ICF provision
• ✕. Left ventricular ejection fraction by echocardiogram or cardiac magnetic resonance (CMR) ≥50% at ≤12 months prior to ICF provision
• ✕. Gene testing indicates that the subject's arrhythmia or cardiomyopathy may be related to a genetic etiology other than PKP2 truncating variant.
• ✕. Concurrent participation in any other clinical investigation involving use of an investigational agent that could confound results of this study.