Early Non-invasive Ventilation and Progressive High Flow Oxygen Therapy Through Tracheostomy Tube Weaning Protocol in Tracheostomized Patients with Prolonged Mechanical Ventilation

Inclusion Criteria: * Age ≥18 years old; * After tracheotomy; * Patients who met the definition of long-term mechanical ventilation (requiring invasive mechanical ventilation for more than 6 hours per day for more than 21 consecutive days); * willing to participate in this study and signed the informed consent. Exclusion Criteria: * The expected survival time less than 3 months; * Participated in another clinical study related to weaning; * death or discharge within 2 weeks after referral; * Unable to cooperate with the study for any reason or considered not suitable for inclusion in the trial by the investigators;