EDX110 - Efficacy and Safety in the Management of Hard-to-heal Wounds

Inclusion Criteria: * Subjects ≥18 years old and willing to participate in all procedures and follow-up evaluations necessary to complete the study * An index ulcer meeting the following characteristics: * Diabetic foot ulcer (DFU): Wagner Grade 1: partial- or full-thickness (superficial) * DFU: Located on the anatomical foot; defined as distal to the medial malleolus * Venous leg ulcer (VLU): Partial or full thickness * VLU: Located below the knee and above the ankle * Presents with or without clinical signs of superficial infection * Present for ≥4 weeks and \<52 weeks * Wounds will be dry to moderately exudating * Post-debridement wound area is ≥0.5 cm2 and ≤25 cm2 * If two or more ulcers are present, the index ulcer must additionally be: * The ulcer with the largest wound area * ≥3cm distance from any other ulcer on the affected limb * DFU: type 1 or type 2 diabetes (confirmed by the subject's medical history) * DFU: HgbA1c \<9% at screening * GFR\>30 mL/min/1,73m2 * Subject has adequate circulation to the affected extremity, as demonstrated by at least one of the following results within the past 30: * Dorsum transcutaneous oxygen test (TcPO2): \>30mmHg; * Subject's Ankle-Brachial Index (ABI) by Doppler: ≥0.7 and ≤1.2; * Doppler arterial waveforms, which are triphasic or biphasic at the ankle of the affected foot. For Ankle-Brachial Pressure Index (ABPI): \>1.2, for Toe Brachial Index (TBI): \>0.5 * A total lymphocyte count of more than 1500…