Not Yet RecruitingPhase 4

Protocol with Progestin-primed Ovarian Stimulation (PPOS) from the Beginning of Stimulation Versus Protocol with GnRH Antagonists for Ovarian Stimulation in Patients Undergoing DUOSTIM with Embryo Accumulation for PGT-A.

144 participantsStarted 2024-10-15

Plain-language summary

The PPOS protocol (Progestin-primed Ovarian Stimulation) involves avoiding ovulation during ovarian stimulation with progesterone. It is a reliable and safe protocol that has been widely used in recent years for in vitro fertilization, as it reduces the number of injections needed during controlled ovarian stimulation and is more cost-effective for patients. The aim of this study is to compare two methods of ovarian stimulation for in vitro fertilization: the PPOS protocol (Group A) and the conventional protocol with injected antagonists (Group B). The goal is to determine whether both methods are equally effective in obtaining euploid embryos in the context of double ovarian stimulation.

Who can participate

Age range18 Years – 43 Years

SexFEMALE

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Regular menstrual cycles between 21 and 35 days, inclusive. * Indication of IVF with PGT-A. * Both ovaries present. * Ability to participate and complete the study. * Give and sign the consent to participate in the study. Exclusion Criteria: * Endometriosis grade III/IV * Concurrent participation in another study

What they're measuring

Number of Euploid Embryos

Timeframe: From date of randomization until the end of the treatment. Assessed up to 12 weeks.

Trial details

NCT IDNCT06637189

SponsorGinefiv

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-15

Contact for this trial

Claudia Blancafort González-Casabón, MD

+34647437121 c.blancafort@ginefiv.com

View on ClinicalTrials.gov More Stimulation in the Ovary trials