Active — Not RecruitingNot Applicable

Different Levels of Blood Flow Restriction Versus Moderate Intensity Exercises in Patients With Knee Osteoarthritis

Egypt75 participantsStarted 2024-10-15

Plain-language summary

This clinical trail will be conducted to investigate the effect of blood flow restriction (BFR) with different load levels between low blood occlusion percentage (50%) group and high blood occlusion percentage (70%) compared to moderate intensity training (60% of 1 RM) in patients with chronic knee osteoarthritis. The main questions it aims to answer are: 1. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on pain intensity in knee osteoarthritis ? 2. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on quadriceps muscle strength in knee osteoarthritis ? 3. Will there be no difference difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on rate of perceived exertion in knee osteoarthritis ? 4. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on functional ability in knee osteoarthritis ? 5. Will there be no difference between the effect of (70% vs 50%) of BFR versus traditional moderate resistive training exercises on physical function in knee osteoarthritis ? All participants will receive: 1. 16 sessions of supervised intervention 2 times per week for 8 weeks. 2. The assessment will be at 3 time points, baseline and at 4 weeks and at 8 weeks.

Who can participate

Age range40 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients diagnosed with chronic knee osteoarthritis referred by orthopedic surgeons participants of both genders age are 40-65. * Patients with grade 2 and 3 OA of the knee, according to radiologic evaluation * If both knees diagnosed as OA, the most affected one will be selected. * Diagnosis of Knee OA who had knee pain and functional disabilities for at least three months, according to American College of Rheumatology classification at screening visit. * Visual Analogue Scale (VAS) at rest score of ≥40 mm. * Arabic version of the western WOMAC (ArWOMAC) scores (average 37). * Moderate Physical activity score on the IPAQ (between 3.0 and 7.9 METS). Exclusion Criteria: * Moderate to significant knee synovitis * Hot or red knee * History and/or physical examination findings compatible with the internal derangement of knee. * Knee pain that is initiated or increased with knee activity/exercise and finished or decreased with knee resting. * Other muscular, articular, or neurological condition affecting lower limb function. * Patients with any previous knee surgeries or fractures of lower limb * Patients who had undergone arthroscopy or treatment with intra-articular hyaluronic acid during the previous 6 months. * Psychological or psychiatric disorders that may affect a subject's participation in the study. * Participants with congenital musculoskeletal lower limb deformity. * Participated in other intervention studies on the past 6 months to screening * …

What they're measuring

Change in pain intensity

Timeframe: Measured 3 times at basline, 4 weeks and 8 weeks

Measure change in quadriceps muscle strength

Timeframe: Measured 3 times at baseline, 4 weeks and 8 weeks

Trial details

NCT IDNCT06637124

SponsorCairo University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-02-26