RecruitingNot Applicable

Accuracy of 68Ga-Pentixafor PET/CT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion

China97 participantsStarted 2024-08-12

Plain-language summary

To evaluate the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of primary aldosteronism concurrent with autonomous cortisol secretion patient, using AVS and/or postoperative remission as the reference standard for classification diagnosis.

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Getting the written informed consent
. The clear diagnosis of primary aldosteronism；
. Combined with autonomous cortisol secretion, cortisol after 1mg dexamethasone suppression test (DST) ≥50 nmol/l；
. Patients who are willing to undergo surgery；
. Adrenal CT or MRI scan of the adrenal glands with nodule (≥1cm).

Exclusion criteria

. PA patients who meet the by-passing AVS criteria \[i.e., younger than 35 years old, spontaneous hypokalemia, adrenal CT indicated unilateral low-density adenoma (≥1cm), plasma aldosterone \&gt;300pg/ml\]；
. Suspicion of familial hyperaldosteronism or Liddle syndrome. \[i.e., age \&lt;20 years, hypertension and hypokalemia, or with family history\]；

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of PA concurrent with ACS patient

Timeframe: 6 months

Trial details

NCT IDNCT06635993

SponsorQifu Li

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-08-12

Contact for this trial

Qi fu Li, PhD

86-89011552 liqifu@yeah.net

View on ClinicalTrials.gov More Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion trials

Who can participate

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Getting the written informed consent
. The clear diagnosis of primary aldosteronism；
. Combined with autonomous cortisol secretion, cortisol after 1mg dexamethasone suppression test (DST) ≥50 nmol/l；
. Patients who are willing to undergo surgery；
. Adrenal CT or MRI scan of the adrenal glands with nodule (≥1cm).

Exclusion criteria

. PA patients who meet the by-passing AVS criteria \[i.e., younger than 35 years old, spontaneous hypokalemia, adrenal CT indicated unilateral low-density adenoma (≥1cm), plasma aldosterone \&gt;300pg/ml\]；
. Suspicion of familial hyperaldosteronism or Liddle syndrome. \[i.e., age \&lt;20 years, hypertension and hypokalemia, or with family history\]；