Active — Not RecruitingNot Applicable

naVIGation Invitations Liver surveillANce upTake

United Kingdom652 participantsStarted 2025-02-27

Plain-language summary

This study aims to evaluate the efficacy of Patient Navigators and mailed surveillance invitations on attendance of Hepatocellular Carcinoma (HCC) ultrasound surveillance appointments. The investigators hypothesise that mailed invitations and Patient Navigators will improve attendance at HCC surveillance appointments and increase the proportion of patients diagnosed at an early stage, compared with a control group receiving usual care.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 18 years of age or older * ECOG performance status of 0-2 * Eligible for HCC surveillance as defined by NICE and EASL criteria * Child Pugh A or B cirrhosis * Child Pugh C cirrhosis AND on liver transplant waiting list * High risk chronic hepatitis B Exclusion Criteria: * Previous or current diagnosis of HCC * Child Pugh C cirrhosis * Frailty (Clinical Frailty Scale \>7) * Previous liver transplant

What they're measuring

Attendance rates at 6-months intervals

Timeframe: 2 years

Proportion of patients in each arm attending HCC surveillance regularly

Timeframe: 2 years

Trial details

NCT IDNCT06635694

SponsorImperial College London

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2027-08-19

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