CompletedNot Applicable

Effect of DCS on Post-Endodontic Pain

Turkey (Türkiye)90 participantsStarted 2024-01-22

Plain-language summary

The aim of this randomized, triple-blind, parallel-group clinical trial was to evaluate the effects of calcium hydroxide (CH), diclofenac sodium (DCS), and their combination (CH+DCS) as intracanal medicaments on post-endodontic pain in mandibular molars diagnosed with symptomatic apical periodontitis. Ninety patients were randomly assigned to three groups (CH, DCS, or CH+DCS; n=30 each). Pain intensity was recorded using a 100 mm Visual Analog Scale (VAS) over 7 days following treatment, and the number of analgesic tablets taken was also recorded. Statistical analyses were performed using Kruskal-Wallis, Friedman, Wilcoxon signed-rank, and Chi-square tests, with significance set at 0.05. The null hypothesis stated that there would be no significant difference in post-endodontic pain among the groups.

Who can participate

Age range18 Years – 60 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age between 18 and 60 years * Systemically healthy (ASA I-II) * Diagnosed with symptomatic irreversible pulpitis or symptomatic apical periodontitis in mandibular molars (characterized by spontaneous pain or prolonged pain in response to cold test, and presence of percussion sensitivity) * Positive response to Electric Pulp Testing (EPT) and cold testing * Periapical Index (PAI) score of 1 or 2 according to Ørstavik et al. (1986) * Pre-operative pain level ≥50 mm on the Visual Analog Scale (VAS), which ranges from 0 (no pain) to 100 (most severe pain) Exclusion Criteria: * History of psychiatric disorders * Allergic reactions * Pregnancy * Use of analgesics within the previous 24 hours * Use of antibiotics within the last 3 months * Teeth with a sinus tract or history of abscess formation * Periodontal pocket depth \>3 mm * Root resorption, root fractures, or ankylosis * Previous root canal treatment on the selected tooth * Teeth requiring prosthetic restoration

What they're measuring

Post-Endodontic Pain

Timeframe: Baseline and Days 1-7 post-treatment

Trial details

NCT IDNCT06632015

SponsorMustafa Kemal University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-05-17