PrEPsmart 2-1-1 Pilot

Inclusion Criteria: * Age 18 years or older * Cisgender-male who reports sex with persons assigned male at birth * Willing and able to provide written informed consent * HIV-uninfected by negative 4th generation HIV test during screening (prescribed group) * Documentation of negative HIV test within the last 3 months by outside laboratory OR evidence of PrEP prescription within the last 6 months based on medical records or pharmacy/provider communication * Owns an iOS or Android mobile phone with a camera and has private access to the internet * Able to understand, read, and speak English * Able to attend study visits at a local research site in San Francisco (Bridge HIV) (prescribed and non-prescribed groups) or virtual visits via a HIPAA-compliant teleconferencing platform (non-prescribed group) * Interested in starting or currently taking on-demand PrEP with TDF/FTC * Report having anal sex at least once a month and expecting to maintain at least this frequency of anal sex during study participation by self-report * Creatinine clearance ≥60 mL/min based on testing done during screening (prescribed group) * Have PrEP clinical and laboratory monitoring by another provider or clinic by self-report (non-prescribed group) * No contraindications to TDF/FTC use * No evidence of chronic HBV infection based on testing done during screening (prescribed group) * Willing to self-collect urine samples weekly Exclusion Criteria: * Repeatedly reactive HIV test at screening or enrollme…