RecruitingNot Applicable

Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity.

Japan60 participantsStarted 2024-08-20

Plain-language summary

The objective of this study is to investigate the efficacy of NMN supplementation in enhancing embryo developmental capacity and improving IVF success rates in patients experiencing IVF failures.

Who can participate

Age range

32 Years – 42 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Agree to participate in the study * 32-42 years old * Having at least one previous embryo implantation failure * History of low Embryo quality at day3 or day5 (according to Veeck's and Gardner's Criteria) * No major uterine or ovarian abnormalities * BMI level 18-25kg/m2 Exclusion Criteria: * Ovarian endometriosis with Chocolate cysts (AFS type 3 and 4) * Patients who have taken different supplements such as coenzyme Q10, vitamin E, carnitine,niacin, nicotinamide, or other vitamin B3-related etc. within the previous month * Any medical contraindication of oocyte retrieval or subsequent procedures * Couples where the husband presents with severe sperm abnormalities * Couples where the husband presents \<5 million/mL motile sperm * Uterine structural anomalies * Polycystic ovaries * Premature ovarian failure * Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc. * Individuals who need drug treatment for any mental illness such as epilepsy and depression. * Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc. * Cancer patients or receiving chemo/radiotherapy treatment within the past 3 years.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Embryo development rate

Timeframe: Up to 8 weeks post-intervention

Changes in metabolic status

Timeframe: Up to 8 weeks post-intervention

Clinical pregnancy rate

Timeframe: Up to 12months post-intervention

Embryo development rate

Timeframe: Up to 8 weeks post-intervention

Embryo development rate

Timeframe: Up to 8 weeks post-intervention

Trial details

NCT IDNCT06629636

SponsorSunkaky Medical Cooperation

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2025-09-30

Contact for this trial

Udayanga KGS., Udayanga Gamage, BVSc, PhD

+81 90 9823 8477 udayanga646@ivfjapan.com

View on ClinicalTrials.gov More Repeated IVF Failure trials

Who can participate

Age range

32 Years – 42 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Embryo development rate

Timeframe: Up to 8 weeks post-intervention

Changes in metabolic status

Timeframe: Up to 8 weeks post-intervention

Clinical pregnancy rate

Timeframe: Up to 12months post-intervention

Embryo development rate

Timeframe: Up to 8 weeks post-intervention

Embryo development rate

Timeframe: Up to 8 weeks post-intervention