Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GD… (NCT06628895) | Clinical Trial Compass
RecruitingNot Applicable
Effect of Modified Poco-Poco Exercise to Frailty Stages, Expression of Global DNA Methylation, GDF15 and Lamin A COP
Indonesia17 participantsStarted 2024-09-15
Plain-language summary
The goal of this clinical trial is to know the effect of multicomponent exercise in frail elderly in community to aging hallmarks. The main question\[s\] it aims to answer are:
1. Do global DNA methylation levels change in elderly people in Bandung after receiving modified poco-poco exercise?
2. Do GDF15 levels change in elderly people in Bandung after they are given modified poco-poco exercise?
3. Do lamin A COP levels change in elderly people in Bandung after they are given modified poco-poco exercise?
4. Does the level of frailty in elderly people in Bandung change after they are given modified poco-poco exercise?
Participants will be asked to do flexibility, balance, aerobic and strengthening exercise included in poco-poco modified exercise three times a week for 12 weeks
Who can participate
Age range60 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Frailty level is in pre-frailty
✓. MoCA INA score above 18
✓. Domicile in Bandung City
✓. Willing to participate in the study after informed consent
Exclusion criteria
✕. There is a hearing impairment that may prevent the subject from receiving verbal instructions
✕. There is uncorrected visual impairment
✕. There are musculoskeletal disorders so that they cannot perform exercise procedures or procedures for measuring research variables
✕. Subjects received other rehabilitation programs
✕. Post-stroke with average limb muscle strength below three
✕. There are diseases that cause impaired cognition such as Alzheimer\'s disease, traumatic head injury, Parkinson\'s disease.
What they're measuring
1
Change From Baseline in Level of Global DNA Methylation in 12 Weeks
Timeframe: week 0 and week 12
2
Change From Baseline in Level of Growth Deficiency Factor (GDF15) in 12 Weeks
Timeframe: week 0 and week 12
3
Change From Baseline in Level of Lamin A (Cyclic Osteo Progenitor) COP in 12 Weeks
Timeframe: week 0 and week 12
4
Change From Baseline in Level of Frailty in 12 Weeks
. There are severe joint diseases such as osteoarthritis and rheumatoid arthritis that may worsen during exercise or may cause difficulty in carrying out the exercise program.
✕. Severe cardiovascular disease as assessed by a heart and vascular specialist