Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans (NCT06627569) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Exercise Effects on the Neurobiology Underlying Stress-related Eating Behaviors in Veterans
United States132 participantsStarted 2026-07-01
Plain-language summary
The purpose of this study is to learn more about how common lifestyle interventions, such as exercise, affect how our brains respond to performing thinking tasks and to viewing pictures of foods and various other objects. The investigators are also interested in how changes in hormones that might be different in men and women could affect how lifestyle interventions change these brain responses.
Who can participate
Age range
18 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Veterans 18-75 years old
* BMI of 25 or greater
* Physically inactive
* Able to attend study visits in person in Aurora, CO
Exclusion Criteria:
* Currently pregnant
* History of bariatric surgery
* Current eating disorder
* Current treatment with appetite-altering medications (e.g., GLP-1 agonists)
* Contraindication to MRI (weight \> 500 lbs; claustrophobia; metal or electronic devices in the body)
* Cardiovascular disease, chronic kidney disease, pulmonary disease, or diabetes
* Unable to exercise due to cardiac, pulmonary, neurologic, or orthopedic reasons
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Percent change in blood oxygen level dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imaging (fMRI)
Timeframe: Baseline, 12 weeks
2
Change in serum cortisol response to counting task