AIM: to compare the sensitivity of SV2A PET and volumetric MRI to detect longitudinal striatal changes in premanifest HD. DESIGN: The investigators will include late premanifest HD mutations carriers and matched healthy controls. All subjects will undergo a clinical examination, with comprehensive assessment of motor and non-motor symptoms, and imaging evaluation consisting of 18F-SynVesT-1 PET and volumetric MRI at baseline and after 2 years.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Baseline differences in synaptic density.
Timeframe: Data analysis will be done when all subjects have undergone the baseline evaluation.
Baseline differences in brain volume.
Timeframe: Data analysis will be done when all subjects have undergone the baseline evaluation.
Differences in the rate of decline of synaptic density.
Timeframe: Data analysis will be done when all subjects have undergone the 2-year follow-up evaluation.
Differences in the rate of decline of volumetric MRI.
Timeframe: Data analysis will be done when all subjects have undergone the 2-year follow-up evaluation.