CompletedPhase 4

Perioperative Nitric Oxide Prevents Acute Kidney Injury in Acute Type A Aortic Dissection Patients

China106 participantsStarted 2024-11-30

Plain-language summary

The goal of this clinical trial is to determine the effectiveness of exogenous nitric oxide therapy in reducing the occurrence of acute kidney injury in patients with acute type A aortic dissection. Additionally, it aims to assess the safety of exogenous nitric oxide therapy.

Who can participate

Age range18 Years – 75 Years

SexALL

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Inclusion criteria

✓. Provide written informed consent;
✓. Participants must be over 18 years of age;
✓. Participants should meet the diagnostic and treatment guidelines for thoracic aortic diseases jointly issued by ACC/AHA in 2022, have received clinical and radiological diagnosis of acute type A aortic dissection, and undergone surgical thoracotomy within two weeks after symptom onset.

Exclusion criteria

✕. Missing baseline value or missing postoperative serum creatinine value (Scr);
✕. Preoperative eGFR less than 30ml/min/1.73m2 or receive renal replacement therapy;
✕. History of kidney disease, including glomerular diseases: acute glomerulonephritis, rapidly progressive glomerulonephritis, chronic glomerulonephritis, nephrotic syndrome, etc., secondary nephropathy: lupus nephritis, diabetic nephropathy, interstitial nephritis, renal tubular disease, chronic renal failure, renal replacement therapy, etc.;
✕. Previous renal tumor, kidney transplantation, and other related surgery;
✕. Patients with single kidney;
✕. History of malignant tumor or received radiotherapy and chemotherapy;
✕. Severe skeletal muscle disease and autoimmune disease;
✕. Preoperative dissection rupture or hemodynamic instability (systolic blood pressure \<90mmHg);

What they're measuring

Acute kidney injury (AKI)

Timeframe: 48 hours

Trial details

NCT IDNCT06622291

SponsorBeijing Anzhen Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-11-01

View on ClinicalTrials.gov More Acute Kidney Injury trials