Active — Not RecruitingNot Applicable

Digital Modeling of Thoracic CT and Pulmonary Fibrosis

France300 participantsStarted 2024-07-01

Plain-language summary

Currently, to our knowledge, there is little data on the combination of tools based on a similar concept to understand and evaluate ILDs. It is expected that this portfolio of multi-tool software implemented in radiology departments, applied to routine thoracic TDM, will provide additional qualitative and quantitative information in real time that will be of great help for diagnosis, prognosis prediction, and treatment decision-making in ILDs.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria: * Informed patients who have consented to participate in the research. * Retrospective data from patients followed for ILDs who underwent two thoracic TDM scans in inspiration and expiration (IE-TDM) at least one year apart, meeting or not meeting the criteria for progressive fibrosis \[presence of two of the following criteria within one year of follow-up: 1/clinical worsening, 2/radiological evidence of disease progression between the two IE-TDM scans, 3/decline in FVC ≥5% or absolute decrease in DLCO (corrected for Hb) \> 10%\]. * 300 records, based on retrospective data, will constitute the initial AVICENNE database (500 records will be selected at Avicenne Hospital APHP so that 300 meet the quality criteria for inspiration/expiration thoracic TDM scans) Exclusion criteria: * Patients under 18 years of age. * Patients under guardianship/curatorship. * Patients under AME (State Medical Assistance).

What they're measuring

Qualitative and quantitative parameters obtained by in silico modeling of interstitial pattern, intra-pulmonary vascular remodeling and airway remodeling.

Timeframe: At 12 months after initial CT scan

Specific mechanical parameters obtained by dynamic poromechanical modeling obtained by dynamic poromechanical modeling.

Timeframe: At 12 months after initial CT scan

Trial details

NCT IDNCT06618924

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2029-07-01

View on ClinicalTrials.gov More Inspiration Expiration Thoracic TDM Sequences of Patients With Diffuse Interstitial Lung Disease (DIP) trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Qualitative and quantitative parameters obtained by in silico modeling of interstitial pattern, intra-pulmonary vascular remodeling and airway remodeling.

Timeframe: At 12 months after initial CT scan

Specific mechanical parameters obtained by dynamic poromechanical modeling obtained by dynamic poromechanical modeling.

Timeframe: At 12 months after initial CT scan